Supplement Reverses Aging And Promotes Healthy Aging – IFLScience

New research finds that supplementing with GlyNAC for seniors — a combination of glycine and N-acetylcysteine ​​— counteracts several key indicators of aging and keeps people healthy as they age. Not only that, but the elderly also seem to be getting fitter and stronger with a slimmer waist after taking them Glinac Appendix.

as stated in Gerontology Journals Series Ascientists at Baylor College of Medicine studied the effect of GlyNAC supplementation in 24 elderly and 12 young adults in a randomized, double-blind, human clinical trial.

After 16 weeks, GlyNAC supplementation was found to be associated with a range of benefits for the major hallmarks of aging and age-related defects. These included oxidative stress, glutathione deficiency, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genetic damage, stem cell fatigue, and cellular aging. Meanwhile, no improvement was observed in those receiving the placebo.

In contrast, older adults who received doses of GlyNAC gained stronger muscles, lower blood pressure, and smaller waist measurements. They could exercise more vigorously, and their walking speed improved, which is a surprisingly good indicator of ill health in old age.

The researchers explain that the key to GlyNAC’s benefits lies in its ability to restore mitochondrial health and correct oxidative stress.

Mitochondria – the “powerhouse of the cell” as the textbooks like to say – generate most of the energy needed to fuel the cell’s biochemical reactions. But as we get older, they understand become less efficient in energy production. exactly like Previous rat studies This clinical trial showed that GlyNAC supplementation appears to raise the mitochondrial function of older adults to levels found in younger adults.

As for oxidative stress, this describes the process in which the body is damaged by high levels of toxic waste products, known as reactive oxygen species or free radicals, leading to cell breakdown and DNA damage. Our body produces a natural antioxidant – glutathione – to counteract this, but its levels also decline as we age. The most recent trial showed that GlyNAC supplementation helps treat glutathione deficiency and reduce oxidative stress in the elderly.

GlyNAC supplementation also appears to have some real effects on participants’ health and well-being. Older adults who received GlyNAC experienced improved muscle strength and increased exercise capacity, as well as a significant improvement in walking speed, which is known to be related To increase the chances of survival in the elderly.

“One interesting question from this trial is why there are so many health-promoting improvements. We believe this is due to the combined effort of three separate ingredients – glycine, cysteine ​​(from NAC) and glutathione, and not just because of glutathione itself,” explains Dr. Rajagopal Sekhar, corresponding study author. and Professor of Medicine at Baylor, in statement.

“Glycine and cysteine ​​are building blocks for the formation of glutathione, which also has health benefits. We believe the improvements in this trial and in our previous studies are the result of the combined effects of glycine, NAC, and glutathione, and we refer to this combination as the ‘Power of 3’,” he added.

Despite the importance of the aging process to everyone, scientists still know surprisingly little about how it occurs. Through clinical trials like this, we can help unravel some of its mysteries and find ways to ensure The number of elderly people in the world is increasing Live a happier and healthier life.

“It is believed that correcting the hallmarks of aging can help people age in a healthy way,” Sekhar added. “However, we do not fully understand why these hallmarks of aging occur in the first place, and therefore there are no proven solutions via randomized human clinical trials to improve or correct hallmarks of aging in older adults.”

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