New antibody neutralizes all known COVID-19 variants – IFLScience

While experts continue to warn that ignoring COVID-19 And 15,000 deaths a day are caused by a fatal mistake, it has become clear that a permanent solution to the virus will require something that neutralizes all the variables of the coronavirus, otherwise we risk constantly falling behind. Now, Harvard researchers think they’ve found just that — a single antibody that neutralizes all known SARS-CoV-2 variants in their lab tests.

The antibody could be used within current vaccination strategies to permanently end the established cycle, if the results are well carried over to human trials. The results have been published in Immunology.

Frederick Alt, HMS Professor Charles A. statement.

“If so, it may provide a new treatment and also contribute to new vaccine strategies.”

To create a broad-spectrum antibody across multiple variants, the researchers turned to previously established mouse models for HIV research. These mice have been transformed into models of our own immune system, identifying exotic pathogens and going through the same trial-and-error motions to create the antibodies that neutralize them. In this way, mice are essentially small machines that can efficiently provide new antibodies for use in treatments.

When exposed to the original SARS-CoV-2 strain first identified in Wuhan, the mouse models created nine different types of antibodies that could bind to the virus, although not all of them were neutralized. Further tests determined that three of these were able to aggressively neutralize the original strain, but one, called SP1-77, was more impressive—it can also neutralize alpha, beta, delta, gamma, and, most importantly, omicron variants.

But how can he stop the virus when its spiny proteins look different due to their different mutations? SP1-77 does not act on the same regions as many other antibodies, and instead selects a region that has not yet mutated in any SARS-CoV-2.

“SP1-77 binds to the spike protein at a site that has not yet been mutated in any variant, and it neutralizes these variants by a new mechanism,” said Thomas Kirchhausen, professor of cell biology at the Blavatnik Institute at HMS.

“These properties may contribute to its broad and powerful activity.”

The researchers have now applied for patents and hope the work will be commercially produced, once the results have been verified in human trials.

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