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Consumption of green vegetables and some nutritional supplements curbs inflammatory bowel disease – Neuroscience News

Summary: Researchers report that eating green vegetables and adding a daily chlorophyllin supplement helps relieve IBD symptoms. In addition, chlorophyllin supplementation greatly helps reduce the risk of mortality associated with IBD.

source: APS

Dietary supplement chlorophyllin relieves inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, according to researchers from the Diabetes and Metabolism Research Center at Sichuan University in China and from Cedars-Sinai Medical Center in Los Angeles.

In addition, chlorophyllin significantly reduces IBD-related mortality, weight loss, diarrhea and occult blood in the stool, damage to the intestinal epithelium and infiltration of inflammatory cells.

The results were published prior to publication in American Journal of Physiology, Gastroenterology and Hepatologyand the study was selected as the APS selected article for the month of August.

Chronic gastrointestinal disorders such as IBD affect tens of millions of people living in the United States, and IBD has created a global health burden due to the high cost of treating the condition.

While the exact cause of IBD is not fully understood, some contributing factors include stress, environmental choices, lifestyle, and diet, such as high consumption of meat or fish.

Chronic inflammation, abnormalities in autophagy — the body’s process of cleaning out damaged cells to make room for newer, healthier cells — and lysosomal stress (a defect in an organelle that leads to inflammation) are also associated with the condition.

This shows a bowl of spinach
The researchers believe these findings could be a pathway to a less invasive treatment for IBD. The image is in the public domain

Current treatments for IBD include medications that suppress the immune system (immunosuppressants) and surgery. However, long-term use of immunosuppressive therapies can lead to severe adverse effects, including opportunistic infections and even organ failure.

In this study, researchers found that oral supplementation of chlorophyllin — a compound derived from the green pigment found in plants — reduced colitis and abnormalities in the intestinal epithelium of mice.

Also, consumption of green vegetables and chlorophyllin may be beneficial in restoring IBD, in part by alleviating inflammation and particulate influx (a process that uses particulate matter to degrade and remove toxic molecules and organelles).

The green pigment in these foods and supplements can trigger nutritional signals to modulate autophagy in cells, dampening IBD symptoms.

The researchers believe these findings could be a pathway to a less invasive treatment for IBD.

“Eating green vegetables or green-tinted supplements such as chlorophyllin may help people with IBD,” said Xiaofeng Zheng, PhD from Sichuan University and one of the study’s authors.

About this diet and inflammation research news

author: press office
source: APS
Contact: Press Office – APS
picture: The image is in the public domain

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original search: open access.
Liver organs on a chip: the pros and cons of complexBy Philip Dalsbecker et al. American Journal of Physiology, Gastroenterology and Hepatology


Summary

Liver organs on a chip: the pros and cons of complex

Physiologically relevant and widely applicable hepatocyte culture platforms are of great interest in both drug development and disease modelling.

Organ-on-a-chip systems offer a promising alternative to conventional two-dimensional (2-D) stationary cultures, providing much-needed signals such as perfusion, shear stress, and three-dimensional (3-D) cell-cell communication.

However, these devices cover a wide range of complexity both in manufacturing and in execution. In this review, we summarize the main features of the human liver that should be reflected in a physiologically relevant liver-on-chip model.

We also discuss the properties of different materials of interest in the production of liver devices on a slide and summarize recent and current advances in this area, highlighting different types of devices with different levels of complexity.

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